The term "Plutonian" can refer to any of the extraterrestrial species from the dwarf planet Pluto found throughout science fiction. Being a frozen world far from the sun, the species in fiction are usually adapted to the harsh environment, and in science the idea of Plutonian life is rarely considered seriously. Based on the fact that silicon life is believed to be better suited to freezing temperatures, Plutonians in fiction show a strong tendency for being silicon-based.
- In Marvel comics, a sapient genetically-engineered species called Pluvians.
- DC comics has a number of pluto-based species throughout its various continuities
- There is a species of flower native to Pluto called the Rainbow Flowers.
- The Martian Manhunter once transformed into a Plutonian Bird-man in order to aprehend a flying crook.
- The Martian Manhunter once came up against a group of Devil-like beings from the planet pluto.
- The Plutonians are the deadly enemies of the Mooninites in the cartoon comedy series Aqua Teen Hunger Force.
- The Plutonians are a stubborn race of aliens that claim Pluto is a planet in the animated sci-fi series Rick and Morty.
- In the The Richie Rich/Scooby-Doo Show segment "Punk Rock Scooby", the Plutonians are a spacefaring species that looks and acts almost exactly like Scrappy-Doo.
- In the novel "Journey to Mars" there is a race of ten foot tall humanoids called Plutonians, these people are not from the actual Pluto however, as the book was written before Pluto's discovery, they are from a destroyed world between Mars and Jupiter that the narrator calls Pluto seemingly for the same reasons that Pluto was named.
- An extinct species of silicon-based crystalline humanoids inhabited Pluto in ancient times, as seen in the Doctor Who New Adventures novel GodEngine.
- The Plutonian Zistles are a sapient crystalline species featured in National Geographic's Picture Atlas of Our Universe, by Roy A. Gallant.
- The Brazilian magazine Superinteressante, in June, 1999, featured speculative non-intelligent alien life forms from each planet of the solar system. Pluto, however, was identified as being home to nothing but frozen viruses, brought there by panspermia and doomed to wait forever for a suitable host to bring them back to life.
- Yuggoth, a world inhabited by the Mi-Go in the Cthulhu Mythos, is often believed to be Pluto. However, the Mi-Go are not natives of that world.